Effect of Testosterone on Central Noradrenergic Nervous System and LHRH
고흥숙(Hong Sook Koh);김경진(Kyung Jin Kim);박종세(Jong Sei Park);고광호(Kwang Ho Ko)
- Abstract
- Relationship between noradrenergic nervous system activity and luteinizing hormone releasing hormone(LHRH) content mediated by testosterone in hypothalamus was tested. Three groups of adult male animals were prepared; (1) Intact; (2) Castration+Vehicle (Cast+V); (3) Castration+Testosterone (Cast+T). Silastic capsule containing vehicle or testosterone was implanted into neck region of animals two weeks following castration. Norepinephrine content, alpha-adrenergic receptor binding characteristics using H3-WB4101, and content of LHRH by LHRH RIA procedure were determined. Testosterone replacement to castrated male rats augmented the content of norepinephrine and LHRH. Testosterone replacement increased the alpha-adrenergic receptor density but did not change alpha-receptor affinity. The data from the present study suggest that increase in LHRH content by testosterone may be positively coupled to the activity of central noradrenergic nervous system.
- Keywords : Testosterone;noradrenergic nervous system;LHRH;hypothalamus.
- August 2024, 68 (4)
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