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Comparison of Prescription Patterns of Tramadol in Pediatric Inpatient and Outpatient between 2017-2018: Cross-sectional analysis
Yakhak Hoeji 2020;64(6):454-460
Published online December 31, 2020
© 2020 The Pharmaceutical Society of Korea.

So-Young Ha, Minjoo Kwak, and Sun-Hong Kwon#

School of Pharmacy, Sungkyunkwan University
Correspondence to: Sun-Hong Kwon, School of Pharmacy, Sungkyunkwan University, Seobu-ro 2066, Jangan-gu, Suwon-si, Gyeonggi-do, South Korea
Tel: +82-10-6808-2498
Received September 4, 2020; Revised October 21, 2020; Accepted December 14, 2020.
Tramadol is a frequently prescribed opioid analgesic for moderate to severe pain. However, tramadol has the potential for misuse by patients and leads to many adverse opioid effects such as central nervous system depression, respiratory depression, and death. Therefore, in December 2017, the Ministry of Food and Drug Safety announced the contraindications for tramadol in pediatric patients under the age of 12 years. The purpose of this study was to analyze the prescribing trends of tramadol in pediatric patients in Korea. To identify prescriptions that included tramadol, we used the 2017 and 2018 databases of the Health Insurance Review and Assessment Service - Pediatric and Adolescent Patient Sample. Among patients under the age of 12, the number of prescriptions per million patients was recorded according to inpatient stay and outpatient visits. The results obtained for 2017 and 2018 were compared to evaluate change. The number of prescriptions for patients under the age of 12 were 2,360 (8.33%) and 2,696 (10.24%) per million patients for inpatient stay and 25,959 (91.60%) and 23,618 (89.70%) per million patients for outpatient visits in 2017 and 2018, respectively. Compared to 2017, in 2018, the tramadol prescription for inpatient stay increased, whereas it decreased for outpatient visits. However, the proportion of tramadol prescription remained high in the clinic. Therefore, our findings suggest the need to promote awareness to reduce the inappropriate use of tramadol in pediatrics.
Keywords : Tramadol, pediatrics, prescription pattern, safety alert 

December 2020, 64 (6)
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