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Fabrication of Theophylline-loaded Sustained Release Tablet via Coupling of Hot Melt Extrusion and 3D Printing
Yakhak Hoeji 2019;63(5):297-302
Published online October 31, 2019
© 2019 The Pharmaceutical Society of Korea.

Eon Soo Song, Youngjun Seo, and Dong Wuk Kim#

College of Pharmacy & Research Institute of Pharmaceutical Sciences, Kyungpook National University
Correspondence to: Dong Wuk Kim, College of Pharmacy & Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, South Korea
Tel: +82-53-950-8579, Fax: +82-53-950-8557 E-mail: dkim17@knu.ac.kr
Received September 20, 2019; Revised October 13, 2019; Accepted October 14, 2019.
Abstract
The objective of this study was to develop a new approach for fabrication of 3D printed tablet containing active pharmaceutical ingredients (APIs), exploiting the hot-melt extrusion (HME) coupled with 3D printing technology. Theophylline was used as a model drug, and hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and stearic acid (SA) were used as a carrier or plasticizer for the preparation of drug-loaded filaments. Four different compositions were hot-melt extruded, and three of them available for 3D printing showed a zero-order sustained release over 9 hours. Overall, 3DP technology coupled with HME could be a novel method to produce controlled release tablets providing the advantage of simplicity and versatility than the conventional method.
Keywords : hydroxypropyl cellulose, hydroxypropyl methylcellulose, theophylline, hot-melt extrusion, fused deposition modeling 3D printing


October 2019, 63 (5)
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