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Synthesis and Evaluation of Sitagliptin Analogs
Yakhak Hoeji 2019;63(4):247-250
Published online August 31, 2019
© 2019 The Pharmaceutical Society of Korea.

Duy Viet Vo and Haeil Park#

College of Pharmacy, Kangwon National University
Correspondence to: #Haeil Park, College of Pharmacy, Kangwon National University, Chunchon 24341, Republic of Korea Tel: +82-33-250-6920 E-mail: haeilp@kangwon.ac.kr
Received July 17, 2019; Revised August 7, 2019; Accepted August 13, 2019.
Abstract
Three sitagliptin analogs with propan-2-amine backbone carbon chain and 1,2,3-triazole were synthesized and evaluated for their DPP-4 inhibitory activity against recombinant human DPP-4 enzyme. All the analogs exhibited moderate to strong inhibitory activities.
Keywords : Sitagliptin, DPP-4 enzyme, antidiabetic agent, fragment structure, backbone carbon chain


October 2019, 63 (5)
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