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Synthesis of Phenyl m-coumarylamide Analogs and Their Anti-platelet Aggregation Activity
Yakhak Hoeji 2019;63(2):70-74
Published online April 30, 2019
© 2019 The Pharmaceutical Society of Korea.

Minwoo Kim, In-hwan Beak#, and Jae-Hwan Kwak#

College of Pharmacy, BB21 Plus Program, Kyungsung University
Correspondence to: #In-hwan Beak, College of Pharmacy, BB21 Plus Program, Kyungsung University, Busan 48434, Korea, Tel: +82-51-663-4880, Fax: +82-51-663-4809, E-mail: beak@ks.ac.kr
Jae-Hwan Kwak, College of Pharmacy, BB21 Plus Program, Kyungsung University, Busan 48434, Korea, Tel: +82-51-663-4889, Fax: +82-51-663-4809, E-mail: jhkwak@ks.ac.kr
Received November 28, 2018; Revised December 19, 2018; Accepted December 21, 2018.
Abstract
Phenyl m-coumarylamide analogs were designed based on phenylpropanoid analogs such as coumaric acid, ferulic acid, and caffeic amide having anti-platelet aggregation activity. They prepared through concise synthetic method. Their anti-platelet aggregation was confirmed using ADP-induced rat platelet by aggregrometer. Compound 1b and 1d having dimethylamine and methoxy group on para-position of phenylamide ring, respectively, exhibit potent inhibitory activity (92.3 and 89.3% at 80 μg/mL). The results suggest that phenyl m-coumrylamide analogs could be used to develop potent anti-platelet aggregation agents.
Keywords : platelet, aggregation, ADP-induced, coumarylamide


April 2019, 63 (2)
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