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Studies on the Components of Coleus foskholii and Forskolin Derivatives
Yakhak Hoeji 2019;63(2):65-69
Published online April 30, 2019
© 2019 The Pharmaceutical Society of Korea.

Yoo Jin Lim and Sang Hyup Lee#

College of Pharmacy, Duksung Women’s University
Correspondence to: #Sang Hyup Lee, College of Pharmacy, Duksung Women’s University, Seoul 01369, Korea, Tel: +82-2-901-8393, E-mail: sanghyup@duksung.ac.kr
Received December 4, 2018; Revised April 4, 2019; Accepted April 8, 2019.
Abstract
Coleus forskholii is an herb growing mainly in India and has been used for medicinal purposes from the ancient times. Forskolin is one of the main components of Coleus forskholii’s root. Several forskolin derivatives in the extracts of root were classified according to the structural features. Forskolin is known to possess a variety of biological activities such as anti-obesity, anti-glaucoma, anti-heart disease, anti-hypertension and oncolytic effects. A lot of biological activities and medicinal effects have been discussed along with mechanistic aspects. In particular, treatment against obesity associated with lean body mass was mentioned. Synthesis of forskolin through several intermediates and the related derivatives were briefly discussed. It is suggested that forskolin and its derivatives deserve to be further investigated for medicinal purposes.
Keywords : Coleus forskholii, forskolin, 1,9-dideoxyforskolin, anti-obesity


April 2019, 63 (2)
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