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Role of Transient Receptor Potential Melastatin (TRPM) Channels in the Stimulation of Melanin Synthesis by Diazoxide
YAKHAK HOEJI 2018;62(6):374-380
Published online December 30, 2018
© 2018 The Pharmaceutical Society of Korea.

Yong Soo Lee#

College of Pharmacy, Duksung Women’s University, Seoul 01369, Korea
Correspondence to: Yong Soo Lee College of Pharmacy, Duksung Women’s University, Seoul 01369, Korea Tel.: +82-2-901-8396 Fax.: +82-2-901-8386 E-mail: yongslee@duksung.ac.kr
Received September 27, 2018; Revised November 5, 2018; Accepted November 6, 2018.
Abstract
The known inhibitors of Ca2+-permeable transient receptor potential melastatin (TRPM) channels, flufenamic acid (FFA) and clotrimazole significantly blocked the diazoxide-induced increase in intracellular Ca2+ concentration ([Ca2+]i) and melanin synthesis in B16 melanoma cells. H2O2 which has been shown to stimulate the activity of the TRPM channels, increased [Ca2+]i and melanin synthesis, which was significantly inhibited by FFA. These results suggest that TRPM channels may play an essential role in the diazoxide-induced melanogenesis through [Ca2+]i increase.
Keywords : diazoxide, melanogenesis, TRPM channel, Ca2+ signal, B16 melanoma cell


February 2019, 63 (1)
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