Inhibitory effects of an extract mixture of ivy (Hedera helix) leaves and Coptidis rhizoma on ovalbumin-induced allergic lung inflammation by co-exposure to Asian sand dust in mice
Chang-Doo Lee*,†, Jung-Kyu Lee*,†, Ji Hoon Jeong***, Eon Sub Park****, Uy Dong Sohn*****, Jong Hyuk Lee******, Jong Wook Shin**,#, and Ji-Yun Lee*,#
*Department of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea
**Department of Internal Medicine, Division of Allergic and Pulmonary Medicine, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea
***Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea
****Department of Pathology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea
*****Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea
******Department of Pharmaceutical Engineering, College of Life and Health Science, Hoseo University Asan 31499, Republic of Korea
**Department of Internal Medicine, Division of Allergic and Pulmonary Medicine, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea
***Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea
****Department of Pathology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea
*****Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea
******Department of Pharmaceutical Engineering, College of Life and Health Science, Hoseo University Asan 31499, Republic of Korea
Correspondence to: Jong Wook Shin
Department of Internal Medicine, Division of Allergic and Pulmonary Medicine, College of Medicine, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
Tel.: 02-6299-1407 Fax.: 02-6299-1448
E-mail: basthma@cau.ac.kr
Ji-Yun Lee
Department of Pathophysiology, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
Tel.: 02-820-5958 Fax.: 02-816-7338
E-mail: jylee98@cau.ac.kr
†These authors contributed equally to this work.
Department of Internal Medicine, Division of Allergic and Pulmonary Medicine, College of Medicine, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
Tel.: 02-6299-1407 Fax.: 02-6299-1448
E-mail: basthma@cau.ac.kr
Ji-Yun Lee
Department of Pathophysiology, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
Tel.: 02-820-5958 Fax.: 02-816-7338
E-mail: jylee98@cau.ac.kr
†These authors contributed equally to this work.
Received January 31, 2018; Revised February 16, 2018; Accepted February 21, 2018.
- Abstract
- Asian sand dust (ASD) is known to cause adverse respiratory health disorders, but there is no beneficial strategies for preventing harmful health effects by ASD. This study aimed to evaluate the inhibitory effects of a combined extract mixture of ivy leaves and Coptidis rhizoma on allergic lung inflammation responses to ASD. Allergic lung inflammation was evoked with ovalbumin (OVA) or OVA plus ASD in a murine asthma model. ASD significantly enhanced allergic lung inflammation in the airway hyperresponsiveness and pathologic changes of the lung in mice compared to the vehicle and OVA controls. Oral administration of a combined extract mixture of ivy leaves and Coptidis rhizoma significantly decreased the infiltration of eosinophils and lymphocytes, and suppressed the releases of Th2 cytokines (IL-4 and IL-5) and chemokine (MCP-1) in bronchoalveolar lavage fluid compared with OVA plus ASD. The anti-inflammatory effect of the extract mixture (25 to 100 mg/kg, p.o.) was similar to that of dexamethasone (1 mg/kg, p.o.). This study suggested a novel insight into the pathological mechanisms underlying the inhibition of ASD-induced allergic asthma via suppression of eosinophilic inflammatory mediators release for the development of new strategies in preventing of the eosinophilic bronchial asthma caused by air-borne dust.
- Keywords : Asian sand dust, Ivy leaves, Coptidis rhizoma, allergic lung inflammation
- August 2024, 68 (4)
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