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Effects of Citrus Essential Oils on Melanin Production in Bl6 Melanoma Cells
YAKHAK HOEJI 2003;47(1):25-30
Published online February 28, 2003
© 2003 The Pharmaceutical Society of Korea.

임혜원(Hye Won Lim);조남영(Nam Young Cho);윤미연(Mi Yun Yoon);차상복(Sang Bok Cha);김경원(Kyoung Won Kim);박영미(Young Mi Park);이지윤(Ji Yun Lee);이진희(Jin Hee Lee);김창종(Chang Jong Kim);심상수(Sang Soo Sim)
Abstract
This study is performed to investigate the effects of citrus essential oils on melanin production in Bl6 melanoma cells. Five kinds of citrus essential oils (Bergamot, Grapefruit, Lemon, Mandarin, Petigrain) did not have any influence on DPPH radical scavenger activity cell growth and cytotoxicity in Bl6 melanoma cells. Both mandarin and petigrain essential oils dose-dependently inhibited purified tyrosinase activity, but bergamot did not. In 1μM MSH-stimulated Bl6 melanoma cells, all of 5 citrus essential oils inhibited melanin production in a dose dependent manner. From the above results, it is possible that citrus essential oils may be development to be an anti-melanogenesis agent on the basis of their inhibitory effect on MSH-induced melanin production.
Keywords : Melanin;tyrosinase;citrus essential oil.


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