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Hypoglycemic and Hypolipidemic Effects of Crude Saponin Fractions from Panax ginseng and Gynostemma pentaphyllum
YAKHAK HOEJI 2001;45(5):545-556
Published online October 31, 2001
© 2001 The Pharmaceutical Society of Korea.

장윤정(Yoon Jung Jang);김중권(Jung Kwon Kim);이명수(Myung Soo Lee);함인혜(In Hye Ham);황완균(Wan Kyun Whang);김기호(Ki Ho Kim);김홍진(Hong Jin Kim)
Abstract
Crude saponin fractions were isolated using non-ionic resin chromatography from Ginseng Radix Alba (PG) and Gynostemmae Herba (GP). These saponin fractions were orally administered to streptozotocin (STZ)-induced diabetic rats for 2 weeks and to high-fat diet-induced obese rats for 4 weeks. Treatment with either PG saponin or GP saponin at a dose of 1 mg/kg significantly decreased the plasma glucose level to that of glibenclamide treated or normal groups. The increased plasma triglyceride (TG) level in diabetic rats was decreased by 50% with PG or GP saponin treatment. Combined administration of PG and GP saponins with different ratios (total dose of 1 mg/kg) also had the similar effects on the blood glucose and TG levels with that of PG or GP alone. Treatments with GP (1 mg/kg) or GP (0.5 mg/kg) and PG (0.5 mgfkg) together signiscantly suppressed the rise in TG levels induced by high-fat diet whereas slightly suppressed the rise in the total cholesterol level. The body weight gain was also decreased both in the two saponin treated groups. These results demonstrate that either alone or mixture of PG and GP have similar degree of effects on hyperglycemia and hyperlipidemia.
Keywords : Saponin;Panax ginseng;Gynostemma pentaphyllum;hyperglycemia;hyperlipidemia;triglyceride;body weight gain.

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