Inhibitory Effects of Polygala tenuifolia Willd., Polygala japonica and Polygala tenuifolia on HCl·ethanol-induced Gastritis in Rats
In Young Hwang, Sun Yi Lee, Suh Yoo Kyung, and Choon Sik Jeong#
College of Pharmacy, Duksung women's University, Seoul 01369, South Korea
Correspondence to: Choon Sik Jeong
College of Pharmacy, Duksung women's University, Seoul 132-714, Republic of Korea
Tel.: 02-2-901-8382 Fax.: 02-901-8386
E-mail: choonsik@duksung.ac.kr
College of Pharmacy, Duksung women's University, Seoul 132-714, Republic of Korea
Tel.: 02-2-901-8382 Fax.: 02-901-8386
E-mail: choonsik@duksung.ac.kr
Received December 2, 2016; Revised January 31, 2017; Accepted February 13, 2017.
- Abstract
- Alcohol, coffee, salty and spicy foods, excessive acid secretion, and NSAIDs increase risk of having a gastritis. Helicobacter pylori (H. pylori), in particular, is known to be a pathogen that is capable of causing gastritis and gastric cancer. Reactive oxygen species and oxidative stress may also play a role as a major factor in gastric injury. In this study, we studied extracts of Polygala tenuifolia Willd. (root), Polygala japonica and Polygala tenuifolia (sprout) for their inhibitory effects on HCl·ethanol-induced gastritis in rats. As a result, extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, reducing power, inhibitory effect on H. pylori colonization and acid-neutralizingcapacity. Especially, the extracts of Polygala tenuifolia Willd. and Polygala japonica significantly inhibited HCl·ethanol-induced gastritis in rat. The results obtained indicate that these extracts might be useful for preventing gastritis.
- Keywords : antioxidant, Helicobacter pylori, gastritis
- August 2024, 68 (4)
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