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Effects of pectin-conjugated Ellagitannin on the IL-1β, Gene Expression of Macrophage
YAKHAK HOEJI 2002;46(3):197-202
Published online June 29, 2002
© 2002 The Pharmaceutical Society of Korea.

김한준(Han Jun Kim);김민수(Min Soo Kim);이민원(Min Won Lee);최영욱(Yong Wook Choi);김하형(Ha Hyung Kim);이도익(Do Ik Lee)
Lectin-conjugated praecoxin A, which has developed as a missile antitumor drug, is the one that has conjugated with wheat germ agglutinin (WGA), a kind of carbohydrate- binding protein (lectin) especially bound to melanoma. Praecoxin A is a kind of tannin extracted and purified from plants. Beside this direct antitumor effect as tannins, we have examined an activation of macrophage by lectin-conjugated praecoxin A. We also confirmed the gene expression of IL-1β, both in vitro and in vivo. We added 1,10,100μg/ml of lectin-conjugated praecoxin A, 10μg/ml of pectin,10μg/ml of praecoxin A to normal murine macrophage and analyzed the extracted total RNAs by RT- PCR after 4,8, 12,24 hours. Our data demonstrated that pectin-conjugated praecoxin A increased IL-1β, mRNA expression in a dose dependent manner. However, the effectiveness of lectin-conjugated praecoxln A was not superior to pectin and praecoxin A.
Keywords : Lectin-conjugated praecoxin A;IL-1beta;anti-tumor.

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