YAKHAK HOEJI

Table. 8.

Table 8 Statistical data for dual-release matrix tablet containing sarpogrelate HCl in simulated intestinal fluid (pH 6.8)

Run #	Zero order			Higuchi model			Hixon-Crowell			First order			Korsmeyer-Peppas model
Run #	R²	K	RSS	R²	K	RSS	R²	K	RSS	R²	K	RSS	R²	K	n	RSS	Mechanism of release
1	0.8542	5.2229	5984.68	0.9790	18.1987	175.7599	0.8450	0.0676	0.4995	0.7855	0.0541	0.4756	0.9416	0.2883	0.3679	0.0074	Fickian diffusion
2	0.8762	5.5876	5672.67	0.9842	20.9406	173.4688	0.8157	0.0797	0.8540	0.7632	0.0641	0.7580	0.9854	0.2545	0.4270	0.0017	Fickian diffusion
3	0.8583	5.6418	6754.44	0.9792	20.1814	213.7139	0.8245	0.0727	0.6699	0.7714	0.0573	0.5783	0.9875	0.2911	0.3979	0.0013	Fickian diffusion
4	0.8084	6.0222	11046.92	0.9439	19.5677	561.4040	0.8226	0.0605	0.4703	0.7941	0.0453	0.3175	0.9597	0.3949	0.2386	0.0015	Fickian diffusion
5	0.8886	5.5240	4915.29	0.9752	21.5235	290.4837	0.7934	0.0865	1.1605	0.7417	0.0712	1.0514	0.9301	0.2186	0.4737	0.0105	Fickian diffusion
6	0.9367	5.2574	2402.46	0.9878	21.7119	143.9017	0.8785	0.0963	0.7634	0.8256	0.0811	0.8279	0.9527	0.1844	0.4876	0.0141	Fickian diffusion
7	0.8047	6.1005	11614.57	0.9345	20.4271	721.8079	0.7293	0.0641	0.9067	0.6892	0.0489	0.6412	0.9966	0.3515	0.3802	0.0002	Fickian diffusion
8	0.8276	5.7899	8979.93	0.9513	20.3759	524.5899	0.7328	0.0701	1.0684	0.6852	0.0553	0.8376	0.9893	0.2945	0.4624	0.0008	Fickian diffusion
9	0.8410	5.7115	7928.28	0.9623	20.4959	406.8550	0.7533	0.0729	1.0359	0.7011	0.0579	0.8522	0.9956	0.2795	0.4621	0.0006	Fickian diffusion
Reference	0.9328	28.6254	442.80	0.9957	27.7660	4.0979	0.9940	0.3294	0.0008	0.9903	0.2911	0.0010	0.9892	0.3832	0.3124	0.0002	Fickian diffusion
Optimzed	0.9236	29.0946	525.21	0.9976	27.6647	2.2538	0.9532	0.2995	0.0055	0.9470	0.2637	0.0049	0.9936	0.3939	0.2899	0.0001	Fickian diffusion