YAKHAK HOEJI

Table. 4.

Table 4 The experimental result of dual-release matrix tablet containing sarpogrelate HCl

Run No.	Independent variable (%, W/W)		Bulk density	Tap density	Haunsner ratio	Carr’s index	Flowability	Weight variation (mg)	Hardness (kgf)	Friability (%)	Content (%)	Dependent variable (%)
Run No.	X₁	X₂	Bulk density	Tap density	Haunsner ratio	Carr’s index	Flowability	Weight variation (mg)	Hardness (kgf)	Friability (%)	Content (%)	Y₁	Y₂	Y₃
1	45	20	0.45	0.51	1.13	11.76	Good	509.57±0.21	6.5±0.6	0.52	98.79±0.68	40.9±9.6	64.8±8.8	100.2±4.50
2	50	15	0.47	0.54	1.15	12.96	Good	510.13±0.58	6.6±0.6	0.44	98.02±0.72	39.9±9.5	067.1±10.0	100.7±4.10
3	50	20	0.46	0.52	1.13	11.54	Good	509.70±0.60	6.5±0.6	0.42	99.24±0.26	038.6±11.5	065.7±12.5	100.3±4.60
4	55	20	0.46	0.52	1.13	11.54	Good	509.43±0.90	6.5±0.5	0.31	98.54±0.73	34.6±7.1	064.4±11.6	98.1±1.2
5	55	15	0.46	0.54	1.17	14.81	Good	509.07±0.71	6.3±0.6	0.43	98.96±1.24	32.6±5.6	59.8±9.1	96.5±2.4
6	50	10	0.51	0.59	1.16	13.56	Good	509.87±0.70	6.6±0.6	0.62	102.98±1.880	38.0±4.5	65.4±5.6	98.6±4.5
7	45	15	0.47	0.55	1.17	14.55	Good	511.20±1.44	6.5±0.5	0.52	99.55±2.55	38.2±4.5	63.4±4.5	98.5±4.5
8	45	10	0.46	0.52	1.13	11.54	Good	509.23±3.42	6.3±0.6	0.34	98.57±1.68	39.9±2.4	65.5±2.2	102.1±3.30
9	55	10	0.45	0.51	1.13	11.76	Good	512.57±0.76	6.4±0.8	0.20	101.45±2.070	38.2±0.6	67.9±6.3	101.9±3.20

X₁: Amount of total polymer to SGH in sustained release part (%, W/W), X₂: Amount of Eudragit^® R SPO to total polymer (%, W/W)

Y₁: Dissolution rate (%) at 2 hour, Y₂: Dissolution rate (%) in 8 hour Y₃: Dissolution rate (%) at 24 hour