YAKHAK HOEJI

Table. 2.

Table 2 Formula according to mixing of EC, pectin, Eudragit^® RSPO and RLPO into HPMC K100M on sustained release part in dual-release matrix tablet containing sarpogrelate HCl

Composition	Formulation (%, W/W)
Composition	F10	F11	F12	F13	F14	F15	F16	F17	F18	F19	F20
SGH	57.05	57.05	57.05	57.05	57.05	57.05	57.05	57.05	57.05	57.05	57.05
CA	2.54	2.54	2.54	2.54	2.54	2.54	2.54	2.54	2.54	2.54	2.54
PVP K30	2.38	2.38	2.38	2.38	2.38	2.38	2.38	2.38	2.38	2.38	2.38
Avicel^® 101	26.15	26.15	26.15	2.38	2.38	2.38	2.38	2.38	2.38	2.38	2.38
HPMC K100M	8.88	5.95	3.01	28.53	23.77	28.53	23.77	28.53	23.77	28.53	23.77
EC	3.01	5.95	8.88	7.13	11.89	-	-	-	-	-	-
Pectin	-	-	-	-	-	7.13	11.89
Eudragit^® RLPO	-	-	-	-	-	-	-	7.13	11.89	-	-
Eudragit^® RS O P	-	-	-	-	-	-	-	-	-	7.13	11.89
Flowability	Fair	Fair	Passable	Excellent	Good	Passable	Passable	Good	Good	Good	Good
Bulk density (kg/m³)	0.45	0.46	0.45	0.46	0.48	0.46	0.47	0.44	0.47	0.44	0.48
Tap density (kg/m³)	0.55	0.55	0.57	0.50	0.56	0.59	0.59	0.49	0.53	0.49	0.54
Hausner’s ratio	1.21	1.20	1.26	1.09	1.17	1.28	1.26	1.11	1.13	1.11	1.13
Carr’s Index	17.27	16.51	20.91	8.00	14.29	22.03	20.34	10.20	11.32	10.20	11.11
Weight variation (mg)	510.21±1.03	512.25±1.27	511.24±5.56	509.21±2.02	506.34±1.07	510.6±1.27	510.40±0.57	508.87±3.13	512.33±1.08	511.07±3.13	513.80±3.21
Content (%)	98.27±1.34	98.45±3.02	98.77±1.22	98.59±0.92	99.06±0.71	100.67±0.42	98.84±0.34	98.63±0.31	98.73±0.32	99.27±2.98	101.23±2.48
Friability (%)	0.20	0.21	0.19	0.18	0.16	0.17	0.24	0.18	0.22	0.15	0.16
Hardness (kgf)	5.7	5.7	5.7	6.3	6.6	5.8	6.9	6.2	5.8	6.4	6.1

Yakhak Hoeji 2024;68:252-68 https://doi.org/10.17480/psk.2024.68.4.252