약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
Table. 1. Formula according to type of polymer on sustained release part in dual-release matrix tablet containing sarpogrelate HCl
Composition Formulation (%, W/W)
F1 F2 F3 F4 F5 F6 F7 F8 F9
SGH 57.05 57.05 57.05 57.05 57.05 57.05 57.05 57.05 57.05
CA 2.54 2.54 2.54 2.54 2.54 2.54 2.54 2.54 2.54
PVP K30 2.38 2.38 2.38 2.38 2.38 2.38 2.38 2.38 2.38
Avicel® 101 26.15 26.15 26.15 26.15 26.15 26.15 26.15 14.26 2.38
HPMC K4M 11.89 - - - - - - -
K15M - 11.89 - - - - - -
K100M - - 11.89 - - - 23.77 35.66
EC - - - 11.89 - - - - -
Pectin1 1.89 - -
Eudragit® RLPO - - - 11.89 - - -
Eudragit® RSPO - - - 11.89 - -
Flowability Good Good Good Fair Fair Fair Fair Good Good
Bulk density (kg/m3) 0.45 0.47 0.46 0.46 0.46 0.50 0.46 0.46 0.45
Tap density (kg/m3) 0.51 0.54 0.52 0.57 0.56 0.59 0.56 0.52 0.51
Hausner’s ratio 1.13 1.15 1.13 1.24 1.22 1.18 1.22 1.13 1.13
Carr’s Index 11.76 12.96 11.54 19.30 17.86 15.25 17.86 11.54 11.76
Weight variation (mg) 509.25±3.59 510.20±0.70 509.38±3.98 508.40±3.81 509.55±0.44 513.05±4.16 507.65±3.12 508.97±1.27 505.26±1.26
Content (%) 99.07±1.23 98.42±1.78 100.74±0.85 99.85±1.54 98.97±0.46 99.44±0.92 98.94±1.04 98.73±1.92 99.73±0.18
Friability (%) 0.24 0.15 0.21 0.18 019 0.17 0.16 0.21 0.20
Hardness (kgf) 5.5 5.6 5.8 6.0 6.0 6.1 5.9 6.0 5.7
Yakhak Hoeji 2024;68:252-68 https://doi.org/10.17480/psk.2024.68.4.252
© 2024 Yakhak Hoeji