ISSN 2383-9457 (ONLINE)

ISSN 0377-9556 (PRINT)

ISSN 2383-9457 (ONLINE)

ISSN 2383-9457 (ONLINE)

Characteristics and performance of prognostic risk models

ncRNA signature of risk model | Number of ncRNAs | Training set | Validation set | Ref | |||
---|---|---|---|---|---|---|---|

Cohort | Performance | Cohort | Performance | ||||

Lnc RNA | m6A RNA methylation | 5 | TCGA (178) |
Poor prognosis for high-risk group ( HR=1.27, 95% CI: 1.07-1.50, AUC values of 1, 2 and 3 years were 0.736, 0.768 and 0.823 |
ICGC (82) |
Poor prognosis for high-risk group, AUC values of 1, 2 and 3 years were 0.682, 0.745, and 0.818 |
1 |

m5C RNA methylation | 8 | TCGA (177) |
Poor prognosis for high-risk group, (HR=2.47, 95% CI: 1.64-3.73, AUC values of 1, and 3 years were 0.716, and 0.639 |
TCGAA group (88) |
Poor prognosis for high-risk group (HR: 2.05, 95% CI: 1.13-3.71, AUC value of 5 years was 0.814 |
9 | |

TCGAB group (88) |
Poor prognosis for high-risk group (HR: 2.56, 95% CI: 1.44-4.56, AUC value of 5 years was 0.903 |
||||||

m6A/m5C/m1A RNA methylation | 7 | TCGA (89) |
Poor prognosis for high-risk group ( HR=1.58, 95% CI: 1.35-1.85, AUC values of 1, 2 and 3 years were 0.834, 0.830, and 0.807 |
TCGA (88) |
Poor prognosis for high-risk group ( HR=1.26, 95% CI: 1.07-1.46, AUC values of 1, 2 and 3 years were 0.652, 0.686, and 0.740; |
10 | |

TCGA (177) |
Poor prognosis for high-risk group ( HR=1.38, 95% CI: 1.25-1.52, AUC values of 1, 2 and 3 years were 0.745, 0.750, and 0.774 |
||||||

PANoptosis | 6 | TCGA (89) |
Poor prognosis for high-risk group ( |
TCGA (89) |
Poor prognosis for high-risk group ( |
11 | |

TCGA (178) |
Poor prognosis for high-risk group ( HR=1.06, 95% CI: 1.03-1.10, *AUC values of 1, 3 and 5 years were 0.772, 0.805, and 0.885 |
||||||

Cuproptosis | 6 | TCGA (89) |
Poor prognosis for high-risk group ( |
TCGA (89) |
Poor prognosis for high-risk group ( |
12 | |

TCGA (178) |
Poor prognosis for high-risk group ( HR=1.29, 95% CI: 1.18-1.40, *AUC values of 1, 3 and 5 years were 0.707, 0.762, and 0.880 |
||||||

EMT | 11 | TCGA (125) |
Poor prognosis for high-risk group ( *HR=2.70, 95% CI: 1.63-4.46, AUC values of 1, 2 and 3 years were 0.754, 0.736, and 0.784 |
TCGA (52) |
Poor prognosis for high-risk group ( HR=33.0, 95% CI: 6.55-187, AUC values of 1, 2 and 3 years were 0.722, 0.846 and 0.951 |
13 | |

TCGA (177) |
Poor prognosis for high-risk group ( HR=3.11, 95% CI: 2.06-4.72, AUC values of 1, 2 and 3 years were 0.742, 0.767 and 0.826 |
||||||

Oxidative stress | 6 | TCGA (84) |
Poor prognosis for high-risk group ( AUC values of 1, 2 and 3 years were 0.701, 0.742, and 0.833 |
TCGA (81) |
Poor prognosis for high-risk group ( AUC values of 1, 2 and 3 years were 0.669, 0.723, and 0.721 |
14 | |

TCGA (165) |
Poor prognosis for high-risk group ( HR=1.13, 95% CI: 1.09-1.18, AUC values of 1, 2 and 3 years were 0.686, 0.724, and 0.770 |
||||||

ICGC-PACA-CA (90) |
Poor prognosis for high-risk group ( HR=1.20, 95% CI: 1.05-1.38, AUC values of 1, 2 and 3 years were 0.654, 0.713, and 0.644 |
||||||

Immune | 9 | TCGA (88) |
Poor prognosis for high-risk group ( *HR=3.35, |
TCGA (88) |
Poor prognosis for high-risk group ( HR=2.05, |
15 | |

TCGA (176) |
Poor prognosis for high-risk group ( HR=2.13, *AUC value of 2 years was 0.703 |
||||||

Genomic instability | 6 | TCGA (87) |
Poor prognosis for high-risk group ( *HR=1.14, 95% CI: 1.09-1.20, |
TCGA (84) |
Poor prognosis for high-risk group ( *HR=1.04, 95% CI: 1.00-1.10, |
16 | |

TCGA (171) |
Poor prognosis for high-risk group ( *AUC value was 0.737 |
||||||

Tumor vs Normal | 3 | TCGA (177) |
Poor prognosis for high-risk group ( *HR=1.91, 95% CI: 1.20-3.05, AUC values of 3, and 5 years were 0.742, and 0.793 |
None | -None | 17 | |

Micro RNA | Prognosis | 7 | TCGA (172) |
Poor prognosis for high-risk group ( AUC values of 1, 2 and 3 years were 0.718, 0.832, and 0.903 |
None | -None | 18 |

Prognosis | 8 | TCGA (146) |
Poor prognosis for high-risk group ( |
GSE 62498 (69) |
Poor prognosis for high-risk group ( |
19 | |

Postoperative recurrence | 3 | FFPE sample (221) |
HR=1.69, 95% CI: 1.25-2.27, |
None | -None | 20 |

*: Dataset unspecified

Yakhak Hoeji 2024;68:152-8 https://doi.org/10.17480/psk.2024.68.3.152

© 2024 Yakhak Hoeji