약학회지

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Table. 3.

Table. 3. Comparative analysis for dosing routes (IP or PO) of acetaminophen on the pharmacokinetics of amifampridine and its metabolite, 3-N-acetylamifampridine, in drug-drug interaction studies.

Data are expressed as means±SDs.

Parameters Amifampridine 3-N-acetylamifampridine
Acetaminophen-IP Acetaminophen-PO Acetaminophen-IP Acetaminophen-PO
AUCcontrol (μg×min/mL) 9.112±1.616 10.16±1.44 221.4±40.7a 224.6±50.7
AUC+acetaminophen (μg×min/mL) 26.03±6.99a 45.66±9.51 221.3±23.5a 231.5±51.6
AUCR 2.857 4.494 1.000 1.030

aData obtained from Ref. 13.

IP, intraperitoneal; PO: per oral; AUCcontrol, AUCinf of control group; AUC+acetaminophen, AUCinf of acetaminophen-treated group; AUCR, ratio of AUC+acetaminophen to AUCcontrol.

Yakhak Hoeji 2024;68:98-104 https://doi.org/10.17480/psk.2024.68.2.98
© 2024 Yakhak Hoeji