ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Data are expressed as means±SDs.
| Pharmacokinetic parameters | Amifampridine | 3-N-acetylamifampridine | ||
|---|---|---|---|---|
| Control | Acetaminophen-treated | Control | Acetaminophen-treated | |
| Cmax (μg/mL) | 0.07333±0.03190 | 000.2028±0.0683 |
0.7812±0.1647 | 000.5270±0.1026 |
| Tmax (min) | 29.00±35.60 | 38.57±27.19 | 72.00±40.25 | 0248.6±171.2 |
| AUClast (μg×min/mL) | 9.661±1.124 | 0039.57±9.02 |
199.3±25.9 | 172.4±33.5 |
| AUCinf (μg×min/mL) | 10.16±1.44 | 0045.66±9.51 |
224.6±50.7 | 231.5±51.6 |
| t1/2 (min) | 96.59±25.20 | 126.0±16.6 | 123.2±42.2 | 220.5±98.1 |
| MRT (min) | 158.5±54.4 | 191.8±25.3 | 231.2±70.4 | 0384.8±110.1 |
| CL/F (mL/min/kg) | 200.1±28.9 | 0045.36±9.38 |
- | - |
| Vd/F (mL/kg) | 27290±4360 | 0008218±2001 |
- | - |
| CLr (mL/min) | 3.135±0.889 | 2.441±0.913 | 4.886±0.490 | 4.573±1.484 |
| AUCm/AUCp | - | - | 21.99±2.33 | 0005.297±1.934 |
AUCm/AUCp, AUCinf ratio of 3-N-acetylamifampridine to amifampridine; CLr, renal clearance.
*p<0.05, **p<0.01 and ***p<0.001 compared with control rats