약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1. Pharmacokinetic parameters of acetaminophen after oral administration of 300 mg/kg acetaminophen in acetaminophen-treated rats (n=7).

Data are expressed as means±SDs.

Parameters Acetaminophen-treated rats
Cmax (μg/mL) 92.23±21.22
Tmax (min) 076.43±111.83
AUClast (μg×min/mL) 30020±10400
AUCinf (μg×min/mL) 110800±89000
t1/2 (min) 774.3±641.2
MRT (min) 1150±913
CL/F (mL/min/kg) 3.718±1.681
Vd/F (mL/kg) 2930±707

AUCinf, area under the plasma concentration-time curve from time 0 to infinity; AUClast, area under the plasma concentration-time curve from time 0 to the last quantifiable point; CL/F, clearance divided by bioavailability (F); Cmax, maximum plasma concentration; Tmax, time to reach Cmax; MRT, mean residence time; t1/2, half-life; Vd/F, volume of distribution divided by F.

Yakhak Hoeji 2024;68:98-104 https://doi.org/10.17480/psk.2024.68.2.98
© 2024 Yakhak Hoeji