ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Statin administration among the subjects in 2003-2013
| Cirrhosis | Hepatocellular carcinoma | ||||||
|---|---|---|---|---|---|---|---|
| Who developed LC | Who did not develop LC | p-value | Who develop HCC | Who did not develop HC | p-value | ||
| Total (N (%)) | 2,964 (5.7) | 49,181 (94.3) | 1,851 (3.7) | 50,294 (96.3) | |||
| Statin use (N (%)) | |||||||
| Non-use (cDDD<30) | 2,247 (75.8) | 34,871 (70.9), | <0.001 | 1,396 (75.4) | 35,722 (71.0) | <0.001 | |
| Use (30≤cDDD) | 717 (24.2) | 14,310 (29.1.) | 455 (24.6) | 14,527 (29.0) | |||
| Cumulative dose of statin use | <0.001 | <0.001 | |||||
| cDDD=0 | 2,120 (71.5) | 32,700 (66.5) | 1,324 (71.5) | 33,496 (66.6) | |||
0| 127 (4.3) |
2,171 (4.4) |
| 72 (3.9) |
2,226 (4.4) |
| | |
| 30≤cDDD<180 | 253 (8.5) | 4,374 (8.9) | 137 (7.4) | 4,490 (8.9) | |||
| 180≤cDDD<720 | 241 (8.1) | 5,130 (10.4) | 176 (9.5) | 5,195 (10.3) | |||
| 720≤cDDD | 223 (7.5) | 4,806 (9.8) | 142 (7.7) | 4,887 (9.7) | |||
| Yearly dose of statin | <0.001 | <0.001 | |||||
| cDDD=0 | 2,120 (71.5) | 32,700 (66.5) | 1,324 (71.5) | 33,496 (66.6) | |||
0| 489 (16.5) |
8,521 (17.3) |
| 291(15.7) |
8,719 (17.3) |
| | |
| 30≤cDDD<120 | 264 (8.9) | 5,787 (11.8) | 178 (9.6) | 5,873 (11.7) | |||
| 120≤cDDD | 91 (3.1) | 2,173 (4.4) | 58 (3.1) | 2,206 (4.4) | |||
| Statin subclass | |||||||
| Atorvastatin | 541 (18.7) | 11,326 (23.0) | <0.001 | 343 (17.5) | 11,524 (22.9) | <0.001 | |
| Rosuvastatin | 119 (4.0) | 2,363 (4.8) | 0.05 | 74 (4.0) | 2,408 (4.8) | 0.117 | |
| Simvastatin | 386 (13.0) | 7,967 (16.2) | <0.001 | 257 (13.9) | 8,096 (16.1) | 0.011 | |
| Pravastatin | 238 (4.7) | 2,264 (4.6) | 0.895 | 84 (4.5) | 2,318 (4.6) | 0.887 | |
| Fluvastatin | 47 (1.6) | 663 (1.4) | 0.278 | 24 (1.2) | 686 (1.4) | 0.806 | |
| Lovastatin | 29 (1.0) | 470 (1.0) | 0.902 | 12 (0.7) | 487 (1.0) | 0.165 | |
| Pitavastatin | 80 (2.7) | 1,649 (3.4) | 0.054 | 50 (2.7) | 1,679 (3.3) | 0.133 | |
| Statin classification | |||||||
| Hydrophilic statin | 767 (25.9) | 15,274 (31.1) | <0.001 | 477 (25.8) | 15,564 (30.9) | <0.001 | |
| Lipophilic statin | 237 (8.0) | 4,332 (8.8) | 0.129 | 148 (8.0) | 4,421 (8.8) | 0.235 | |