약학회지

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Table. 1.

Table. 1.

Baseline characteristics of subjects included on 1 January 2003

Cirrhosis Hepatocellular carcinoma


Who developed LC Who did not develop LC p-value Who develop HCC Who did not develop HC p-value
Total (N (%)) 2,964 (5.7) 49,181 (94.3) 1,851 (3.6) 50,294 (96.4)

Age group (N (%)) <0.001 <0.001
20~39 594 (20.0) 15,889 (32.3) 401 (21.7) 16,092 (32.0)
40~59 1,579 (53.3) 22,181 (45.1) 950 (51.3) 22,810 (45.3)
60~ 791 (26.7) 11,101 (22.6) 500 (27.0) 11,392 (22.7)

Sex (N (%)) <0.001 1
Men 2,030 (68.5) 24,747 (50.3) 1,262 (68.2) 25,515 (50.7)
Women 934 (31.5) 24,434 (49.7) 589 (31.8) 24,779 (49.3)

Comorbidity
Cardiovascular disease No 2,714 (91.6) 44,589 (89.3) <0.001 1,703 (92.0) 45,240 (89.5) <0.001
Yes 250 (8.4) 4,592 (10.7) 148 (8.0) 5,054 (10.5)
Diabetes mellitus No 2,623 (88.5) 44,772 (91.0) <0.001 1,653 (89.3) 45,742 (90.9) <0.001
Yes 341 (11.5) 4,409 (9.0) 198 (10.7) 4,552 (9.1)
Hypertension No 2,209 (74.5) 37,000 (75.2) <0.001 1,384 (74.8) 37,825 (72.1) 0.021
Yes 755 (15.3) 12,181 (24.8) 467 (25.2) 12,469 (24.8)
Cerebrovascular disease No 2,884 (97.3) 47,519 (96.6) <0.001 1,798 (97.1) 48,605 (96.4) 0.003
Yes 80 (2.7) 1,662 (3.4) 53 (13.8) 1,689 (3.6)

Liver disease
Hepatitis B virus No 2,832 (94.5) 46,921 (95.3) <0.001 1,768 (96.5) 47,985 (95.4) <0.001
Yes 132 (5.5) 2,260 (4.6) 83 (3.5) 2,309 (4.6)
Hepatitis C virus No 2,902 (97.1) 48,351 (98.3) <0.001 1,807 (90.6) 49,446 (98.3) <0.001
Yes 62 (2.1) 830 (1.7) 44 (2.4) 848 (1.7)
Other chronic hepatitis No 2,081 (70.2) 37,654 (76.6) <0.001 1,320 (71.3) 38,415 (76.4) <0.001
Yes 883 (29.8) 11,527 (23.4) 531 (28.7) 11,879 (23.6)
NAFLD No 2,640 (89.1) 42,611 (86.6) <0.001 1,658 (89.6) 43,593 (86.7) <0.001
Yes 324 (10.9) 6,570 (13.4) 193 (10.4) 6,701 (13.3)
Alcoholic liver disease No 2,366 (79.8) 42,700 (86.8) <0.001 1,562 (84.4) 43,504 (86.5) <0.001
Yes 598 (20.2) 6,481 (13.2) 289 (15.6) 6,790 (13.5)
Toxic liver disease No 2,822 (95.1) 46,424 (94.4) <0.001 1,773 (95.8) 47,473 (94.4) <0.001
Yes 142 (4.9) 2,757 (5.6) 78 (4.2) 2,821 (5.6)

Medication (N (%))
Anti-diabetic drugs No 2,608 (88.0) 45,021 (91.5) <0.001 1,643 (88.8) 45,989 (91.4) <0.001
Yes 356 (12.0) 4,157 (8.5) 208 (11.2) 4,305 (8.6)
Anti-hypertensive drugs No 2,146 (72.4) 36,014 (73.2) <0.001 1,346 (72.7) 36,817 (73.2) <0.001
Yes 818 (27.6) 13,164 (26.8) 505 (27.3) 13,477 (26.8)
Lipid-lowering agents (except statin) No 2,912 (98.2) 48,158 (97.6) 0.035 1,818 (98.2) 49255 (97.9) 0.674
Yes 52 (1.7) 1,020 (2.4) 33 (1.8) 1,039 (2.1)
Yakhak Hoeji 2024;68:44-55 https://doi.org/10.17480/psk.2024.68.1.44
© 2024 Yakhak Hoeji