약학회지

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Table. 3.

Table. 3.

Causal inference approach of the association of statin use with cirrhosis and hepatocellular carcinoma

Outcome Statin use (N) IPW Analysis Superlearning TMLE


Marginal OR 95%CI Marginal OR 95%CI
Cirrhosis Non-use (37,118) 1 (Ref) 1 (Ref)
Use (15,027) 0.64** 0.57-0.71 0.58** 0.50-0.65

Hepatocellular carcinoma Non-use (37,118) 1 (Ref) 1 (Ref)
Use (15,027) 0.61** 0.53-0.70 0.59** 0.50-0.67

Marginal odds ratio for causal inference from inverse probability weighting(IPW) with adjustment for dyslipidemia, cardiovascular disease, high blood pressure, cerebrovascular disease, diabetes mellitus, antihypertensive medication, antidiabetic medication, and lipid-lowering agents (except statin).

Marginal odds ratio for causal inference from targeted maximum likelihood estimation (TMLE) with adjustment for dyslipidemia, cardiovascular disease, high blood pressure, cerebrovascular disease, diabetes mellitus, antihypertensive medication, antidiabetic medication, and lipid-lowering agents (except statin).

* p<0.05, ** p<0.01

Yakhak Hoeji 2024;68:44-55 https://doi.org/10.17480/psk.2024.68.1.44
© 2024 Yakhak Hoeji