약학회지

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Table. 2.

Table. 2.

Baseline characteristics of TDF group and TAF group after IPTW

TDF TAF p-value aSD
Age: % 0.996 0.005
20-34 years 12.4 12.5
35-49 years 41.8 41.9
50-64 years 38.2 38.0
65- years 7.6 7.5
Female: % 39.0 39.3 0.800 0.005
Insurance: % 0.859 0.004
National health insurance 96.6 96.5
Medical aid, Veterans 3.4 3.5
Liver transplant status: % 0.2 0.0 <0.001 0.063
Fracture history: % 0.0 0.0 0.318 0.013
Charlson Comorbidity Index: mean (SD) 0.83 (0.98) 0.83 (0.94) 0.866 0.003
Co-medication: %
Hormonal therapy
Glucocorticoids 34.0 34.0 0.983 <0.001
Thyroid hormone 1.8 1.8 0.915 0.002
Aromatase inhibitors 0.2 0.1 0.871 0.006
Ovarian suppressing agents 0.6 0.5 0.787 0.006
Androgen deprivation therapy 0.2 0.2 0.814 0.007
Thiazolidinediones 0.8 0.8 0.861 0.004
Psychotropic and anticonvulsant therapy
SSRI 2.6 2.7 0.913 0.002
Anticonvulsants 0.0 0.0 - <0.001
Drugs used for cardiovascular diseases
Heparins 2.0 2.0 0.931 0.002
Loop diuretics 4.5 4.5 0.922 0.002
Drugs targeting the immune system
Calcineurin inhibitors 0.6 0.4 0.132 0.028
Drugs used for gastrointestinal diseases
Proton pump inhibitors 35.3 35.3 0.926 0.002
Comorbidity: %
HCV co-infection 1.3 1.3 0.991 <0.001
Endocrine disorders
Hyperthyroidism 0.0 0.0 0.026 0.030
Hypogonadism 0.2 0.2 0.952 0.001
Hyperparathyroidism 0.1 0.1 0.881 0.003
Diabetes mellitus 0.2 0.2 0.792 0.006
Growth hormone deficiency and acromegaly 0.0 0.0 - <0.001
Cushing syndrome 0.1 0.1 0.989 <0.001
Gastrointestinal, hepatic, and nutritional disorders
Celiac disease & malabsorption 0.0 0.0 - <0.001
Inflammatory bowel disease 0.0 0.0 - <0.001
Gastric bypass surgery 0.0 0.0 - <0.001
Anorexia nervosa 0.0 0.0 - <0.001
Hematological disorders
Multiple myeloma 0.1 0.1 0.751 0.006
Renal disorders
Idiopathic hypercalciuria 1.6 1.6 0.887 0.003
Chronic kidney disease 0.3 0.3 0.918 0.002
Autoimmune disorders
Rheumatoid arthritis 0.0 0.1 0.697 0.009
Systemic lupus erythematosus 0.0 0.0 - <0.001
Ankylosing spondylitis 0.0 0.0 0.318 0.013
Chronic obstructive pulmonary disease 3.0 3.1 0.965 0.001

Abbreviations: TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate; aSD, absolute standardized difference; SSRI, selective serotonin reuptake inhibitor; HCV, hepatitis C virus; SD, standard deviation; IPTW, inverse probability of treatment weighting

Yakhak Hoeji 2024;68:26-35 https://doi.org/10.17480/psk.2024.68.1.26
© 2024 Yakhak Hoeji