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Table. 4. Regression coefficient (R2) values of sarpogrelate HCl release data obtained from developed OROS tablet
Formulation Zero order Higuchi model Hixon-Crowell First order Peppas model Mechanism of release **Tx% (hr)
k n *R2adjusted T20% T40% T60%
A 0.9927 0.9844 0.9172 0.7235 0.0202 1.2485 0.9949 Super case II 6.27 10.93 15.12
B 0.9870 0.9538 0.8283 0.8273 0.0075 1.5729 0.9720 Super case II 8.06 12.53 16.21
C 0.9747 0.9840 0.8815 0.6710 0.0215 1.299 0.9969 Super case II 5.56 9.49 12.97
D 0.9788 0.9868 0.8028 0.6448 0.0300 1.1674 0.9980 Super case II 5.07 9.20 13.01
E 0.9913 0.9803 0.7960 0.7961 0.0220 1.2226 0.9999 Super case II 6.08 10.72 14.94
F 0.9809 0.9890 0.8570 0.7501 0.0323 1.1519 0.9910 Super case II 4.87 8.89 12.63
C-1 0.9536 0.9735 0.8266 0.7065 0.0211 1.3485 0.9948 Super case II 5.30 8.87 11.97
C-2 0.9911 0.9681 0.7699 0.7903 0.0113 1.3710 0.9950 Super case II 8.13 13.48 18.12
C-3 0.76 0.7962 0.8488 0.4987 0.0295 1.6427 0.9942 Super case II 3.21 4.89 6.26
C-4 0.7654 0.8020 0.5321 0.5317 0.0433 1.3520 0.9976 Super case II 3.10 5.18 6.99
C-5 0.9818 0.9793 0.5289 0.6959 0.0156 1.3626 0.9960 Super case II 6.50 10.81 14.56
C-6 0.9802 0.9811 0.8142 0.7742 0.0166 1.3623 0.9963 Super case II 6.22 10.33 13.92
C-7 0.9839 0.9848 0.8189 0.7821 0.0236 1.2458 0.9989 Super case II 5.56 9.70 13.43
Uncoated C 0.5423 0.777 0.3657 0.4426 0.2304 0.8709 0.9980 non-Fickian release 0.85 1.88 3.00
D 0.4514 0.6919 0.3144 0.3434 0.2811 0.9596 0.9944 Super case II 0.70 1.44 2.20
E 0.4124 0.9105 0.2877 0.3165 0.3304 0.8677 0.9956 non-Fickian release 0.56 1.25 1.99
Reference 0.7200 0.9139 0.8595 0.7862 0.4056 0.2967 0.9934 - 0.09 0.95 3.74

*R2adjusted=1-(n-1)/(n-p)*(1-R2), where n is the number of data, p is the number of estimated parameter, R2 is the correlation coefficient.

**Tx% is the time for % release (Tx%) from OROS tablet containing SGH.
Yakhak Hoeji 2023;67:360-71 https://doi.org/10.17480/psk.2023.67.6.360
© 2023 Yakhak Hoeji