약학회지

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Table. 3.

Table. 3. The similarity factor (f2) of Anplag tablet, Sarpodifil SR and developed OROS tablet between distilled water and pH 1.2 (SGF), pH 4.0 and pH 6.8 (SIF) at initial, intermediate and end point (Mean±SD, n=4)
Sample Time Distilled water pH 1.2 (SGF)
pH 1.2 (SGF) pH 4.0 pH 6.8 (SIF) pH 4.0 pH 6.8 (SIF)
SarpodifilSR Initial 47.8±3.3 95.8±3.6 91.1±5.4 481.±4.2 48.5±3.5
Intermediate 40.6±1.8 82.3±4.8 71.2±6.3 39.7±3.0 46.3±2.5
End 40.3±1.6 81.4±3.3 70.2±4.8 39.4±3.5 44.6±2.0
OROS tablet Initial 97.3±0.8 99.5±0.5 99.0±0.3 98.7±0.7 99.4±0.3
Intermediate 70.8±12.2 80.9±10.6 75.4±12.0 71.3±21.6 63.4±7.6
End 67.8±14.8 73.4±9.6 66.3±11.7 67.4±24.0 55.8±6.7

Initial : 0~2hr, Intermediate : 2~12hr, End : 12~24hr

Yakhak Hoeji 2023;67:360-71 https://doi.org/10.17480/psk.2023.67.6.360
© 2023 Yakhak Hoeji