약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 2.

Table. 2. Formulation of OROS tablet containing sarpogrelate HCl according to affecting factor on dissolution rate
Component Formulation (%)
C C-1 C-2 C-3 C-4 C-5 C-6 C-7
Coating ratio (CA/:PEG 3350) 9:1 8 6 10 - - 8 8 8
8:2 - - - 8 - - - -
7:3 - - - - 8 - - -
Orifice size (mm) & number 0.8 - - - - - 1 - -
1.0 - - - - - - 1 -
1.2 1 1 1 1 1 - - 2
Coated tablet Thickness (mm) 9.99±0.29 10.15±0.02 10.19±0.01 10.19±0.03 10.20±0.03 9.54±0.31 9.54±0.31 9.54±0.31
Weight variation (mg)Weight (mg) 1079.39±5.65 1060.20±5.30 1078.82±5.59 1080.31±3.35 1080.72±3.92 1078.82±5.59 1078.82±5.59 1078.82±5.59

*Uncoated tablet of all formula were prepared with 8.94±0.31 KP of hardness, 9.26±0.03 mm of thickness and 999.20±5.92 mg of weight.

Yakhak Hoeji 2023;67:360-71 https://doi.org/10.17480/psk.2023.67.6.360
© 2023 Yakhak Hoeji