약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1. Formulation of OROS tablet containing sarpogrelate HCl
Layer Component Formulation (%)
A B C D E F
Drug SGH 44.8 44.8 44.8 44.8 44.8 50.0
L100-PEO 48.7 - - - - -
L200-PEO - 48.7 48.7 38.7 28.7 42.7
NaCl - - - 10.0 20.0 -
Citric acid 6.0 6.0 6.0 6.0 6.0 6.7
St-Mg 0.6 0.6 0.6 0.6 0.6 0.6
Carr’s index 25.0 28.1 29.4 25.5 24.8 26.3
Hausner ratio 1.33 11.8.39 1.42 1.34 1.33 1.36
Flowability Poor Poor Poor Poor Poor Poor
Push H4,000-PEO - 60.6 - - - -
H5,000-PEO 60.6 - 60.6 60.6 60.6 60
NaCl 38.8 38.8 38.8 38.8 38.8 39.5
St-Mg 0.5 0.5 0.5 0.5 0.5 0.5
Fe2O3 0.1 0.1 0.1 0.1 0.1 0.1
Carr’s index 12.5 11.8 13.6 13.6 13.6 12.6
Hausner ratio 1.14 1.13 1.16 1.16 1.16 1.14
Flowability Good Good Good Good Good Good
Uncoated tablet Hardness (KP) 8.87±0.41 8.94± 0.21 8.94±0.31 8.76±0.38 8.82±0.37 8.90± 0.36
Thickness (mm) 9.35±0.06 9.78±0.11 9.26±0.03 9.70±0.07 9.20±0.04 10.41±0.11
Weight variation (mg) 998.66±3.68 999.13±3.07 999.20±5.92 999.31±3.44 1001.54±4.16 998.57±3.52
Coated tablet Thickness (mm) 9.72±0.12 9.54±0.31 9.99±029 9.89±0.32 9.51±0.28 10.73±0.41
Weight variation (mg)Weight (mg) 1079.22±4.08 1078.82±5.59 1079.39±5.65 1078.82±5.59 1082.31±4.98 1077.25±6.82

*Drug : push layer ratio in all formula exception of formulation F (1.5:1) was 2:1.

**Coating ratio and orifice number in all formula were 8% with CA/PEG 3350 (9:1) and one with 1.2 mm size.

Yakhak Hoeji 2023;67:360-71 https://doi.org/10.17480/psk.2023.67.6.360
© 2023 Yakhak Hoeji