약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1. Circular RNAs regulating retinal vascular diseases
Disease circRNA Target miRNA Expression Study model Function Mechanism of action Reference
ROP circZNF609 miR-615-5p Up In vitro) Hypoxia-treated HUVEC Promotes cell proliferation, migration and tube formation Regulates MEF2A expression by acting as a sponge for miR-615-5p 59)
In vivo) OIR mouse
circPDE4B miR-181c Down In vitro) Hypoxia-treated HREC Suppresses cell proliferation and tube formation Modulates VHL expression by acting as a sponge for miR-181c and facilitatethe ubiquitin degradation of HIF-1α 61)
In vivo) OIR mouse
AMD circZBTB44 miR-578 Up In vitro) CoCl2-treated RF/6A Promotes cell proliferation, migration and tube formation Acts as a sponge for miR-578 and upregulates expression of VEGFA and VCAM1 63)
In vivo) Laser-induced CNV mouse
circNR3C1 miR-382-5p Down In vitro) NaIO3-treated ARPE-19 Increases expression of epithelial-specific marker and decreases cell proliferation Sponges miR-382-5p and regluates expression of PTEN/AKT/mTOR 67)
In vivo) C57BL/6 mouse
DR circZNF532 miR-29a-3p Up In vitro) high glucose medium cultured Human retinal pericyte and HRVEC Promotes cell viability and pericyte function Acts as a sponge for miR-29a-3p and increases expression of NG2, LOXL2 and CDK2 71)
In vivo) STZ-induced diabetic mouse
circHIPK3 miR-30a-3p Up In vitro) high glucose medium cultured HRVEC Promotes cell viability, proliferation, migration and induces tube formation Acts as an endogenous miR-30a-3p sponge and upregulates expression of VEGFC, FZD4, WNT2 75)
In vivo) STZ-induced diabetic mouse
circDNMT3B miR-20b-5p Down In vitro) high glucose medium cultured HRMEC Upregulates expression of tight junction-related protein and promotes cell proliferation and migration Regulates BAMBI expression by acting as a sponge for miR-20b-5p 74)
In vivo) Diabetic rat model

Abbreviations: AKT, Protein kinase B; AMD, Age-related Macular Degeneration; ARPE-19, Arising Retinal Pigment Epithelia-19 cell; BAMBI, BMP and Activin Membrane-Bound Inhibitor homolog; CDK2, Cyclin-Dependent Kinase 2; CNV, Choroidal Neovascularization; DR, Diabetic Retinopathy; FZD4, Frizzled class receptor 4; HIF, Hypoxia-Inducible Factor; HREC, Human Retinal Endothelial Cell; HRMEC, Human Retinal Microvascular Endothelial Cells; HRVEC, Human Retinal Vascular Endothelial Cell; HUVEC, Human Umbilical Vein Endothelial Cell; LOXL2, Lysyl Oxidase Like 2; MEF2A, Myocyte Enhancer Factor 2A; mTOR, mammalian Target Of Rapamycin; NG2, Neural/Glial antigen 2; OIR, Oxygen-Induced Retinopathy; PTEN, Phosphatase and Tensin homolog; ROP, Retinopathy Of Prematurity; STZ, Streptozotocin; VCAM1, Vascular Cell Adhesion Molecule 1; VEGFA : Vascular Endothelial Growth Factor-A; VEGFC, Vascular Endothelial Growth Factor-C; VHL, Von Hippel-Lindau; WNT2, Wnt family member 2

Yakhak Hoeji 2023;67:325-34 https://doi.org/10.17480/psk.2023.67.6.325
© 2023 Yakhak Hoeji