YAKHAK HOEJI

Table. 1.

Table 1Circular RNAs regulating retinal vascular diseases

Disease	circRNA	Target miRNA	Expression	Study model	Function	Mechanism of action	Reference
ROP	circZNF609	miR-615-5p	Up	In vitro) Hypoxia-treated HUVEC	Promotes cell proliferation, migration and tube formation	Regulates MEF2A expression by acting as a sponge for miR-615-5p	59)
	circZNF609	miR-615-5p	Up	In vivo) OIR mouse	Promotes cell proliferation, migration and tube formation		59)
	circPDE4B	miR-181c	Down	In vitro) Hypoxia-treated HREC	Suppresses cell proliferation and tube formation	Modulates VHL expression by acting as a sponge for miR-181c and facilitatethe ubiquitin degradation of HIF-1α	61)
	circPDE4B	miR-181c	Down	In vivo) OIR mouse	Suppresses cell proliferation and tube formation		61)
AMD	circZBTB44	miR-578	Up	In vitro) CoCl2-treated RF/6A	Promotes cell proliferation, migration and tube formation	Acts as a sponge for miR-578 and upregulates expression of VEGFA and VCAM1	63)
	circZBTB44	miR-578	Up	In vivo) Laser-induced CNV mouse	Promotes cell proliferation, migration and tube formation		63)
	circNR3C1	miR-382-5p	Down	In vitro) NaIO3-treated ARPE-19	Increases expression of epithelial-specific marker and decreases cell proliferation	Sponges miR-382-5p and regluates expression of PTEN/AKT/mTOR	67)
	circNR3C1	miR-382-5p	Down	In vivo) C57BL/6 mouse			67)
DR	circZNF532	miR-29a-3p	Up	In vitro) high glucose medium cultured Human retinal pericyte and HRVEC	Promotes cell viability and pericyte function	Acts as a sponge for miR-29a-3p and increases expression of NG2, LOXL2 and CDK2	71)
	circZNF532	miR-29a-3p	Up	In vivo) STZ-induced diabetic mouse	Promotes cell viability and pericyte function		71)
	circHIPK3	miR-30a-3p	Up	In vitro) high glucose medium cultured HRVEC	Promotes cell viability, proliferation, migration and induces tube formation	Acts as an endogenous miR-30a-3p sponge and upregulates expression of VEGFC, FZD4, WNT2	75)
	circHIPK3	miR-30a-3p	Up	In vivo) STZ-induced diabetic mouse			75)
	circDNMT3B	miR-20b-5p	Down	In vitro) high glucose medium cultured HRMEC	Upregulates expression of tight junction-related protein and promotes cell proliferation and migration	Regulates BAMBI expression by acting as a sponge for miR-20b-5p	74)
	circDNMT3B	miR-20b-5p	Down	In vivo) Diabetic rat model			74)

Abbreviations: AKT, Protein kinase B; AMD, Age-related Macular Degeneration; ARPE-19, Arising Retinal Pigment Epithelia-19 cell; BAMBI, BMP and Activin Membrane-Bound Inhibitor homolog; CDK2, Cyclin-Dependent Kinase 2; CNV, Choroidal Neovascularization; DR, Diabetic Retinopathy; FZD4, Frizzled class receptor 4; HIF, Hypoxia-Inducible Factor; HREC, Human Retinal Endothelial Cell; HRMEC, Human Retinal Microvascular Endothelial Cells; HRVEC, Human Retinal Vascular Endothelial Cell; HUVEC, Human Umbilical Vein Endothelial Cell; LOXL2, Lysyl Oxidase Like 2; MEF2A, Myocyte Enhancer Factor 2A; mTOR, mammalian Target Of Rapamycin; NG2, Neural/Glial antigen 2; OIR, Oxygen-Induced Retinopathy; PTEN, Phosphatase and Tensin homolog; ROP, Retinopathy Of Prematurity; STZ, Streptozotocin; VCAM1, Vascular Cell Adhesion Molecule 1; VEGFA : Vascular Endothelial Growth Factor-A; VEGFC, Vascular Endothelial Growth Factor-C; VHL, Von Hippel-Lindau; WNT2, Wnt family member 2

Yakhak Hoeji 2023;67:325-34 https://doi.org/10.17480/psk.2023.67.6.325