약학회지

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Table. 3.

Table. 3.

Detected signals for concomitant use of warfarin and statin

Drug No. of drug-AE reports Ω shrinkage measure model Chi-square statistics Signal detection
Ω025F Ω025B χ Ω025F Ω025B χ
Dyspnoea 33 0.29 0.29 3.11 Y Y Y
Palpitation 27 1.23 1.21 6.89 Y Y Y
Syncope 12 1.67 1.56 7.43 Y Y Y
Oedema 11 0.12 0.09 2.21 Y Y Y
Atrial fibrillation 11 0.72 0.58 3.89 Y Y Y
Arthralgia 10 0.09 -0.04 2.14 Y N Y
Prostatic Hyperplasia 6 0.27 0.23 2.59 Y Y Y
Hyperuricaemia 4 0.54 0.24 3.48 Y Y Y
Medical Device Complication 4 1.54 1.25 12.11 Y Y Y
Convulsions 3 -0.05 -0.29 2.23 N N Y
Pleural effusion 3 -0.07 -0.57 2.19 N N Y
Haemorrhage rectum 3 -0.14 -0.71 2.03 N N Y
Musculoskeletal disorder 3 -0.12 -0.53 2.09 N N Y
Tenesmus 2 0.16 -0.94 5.99 Y N Y
Hyperthyroidism 2 0.04 -0.18 4.27 Y N Y
Menopausal Symptoms 2 0.04 -0.38 4.27 Y N Y
Ptosis 2 -0.08 -0.83 3.36 N N Y
Depersonalization 2 -0.07 -0.63 3.43 N N Y
Musculoskeletal disorder 2 -0.07 -0.91 3.41 N N Y
Gastrointestinal NOS 2 -0.19 -0.7 2.79 N N Y
Skin Hypertrophy 1 -1.28 -2.42 4.23 N N Y
Pleural Pain 1 -1.3 -2.24 3.37 N N Y
Myeloproliferative Disorder 1 -1.32 -2.29 2.9 N N Y
Oedema Cerebral 1 -1.32 -2.48 2.9 N N Y
Lipoma 1 -1.32 -2.37 2.9 N N Y
Breath Odour NOS 1 -1.32 -2.02 2.9 N N Y
Osteitis 1 -1.27 -2.31 4.78 N N Y

AE: adverse events; Ω: omega; χ: chi; Ω025F: motivated from frequentist perspective; Ω025B: motivated from Bayesian perspective; Y: index satisfied with signal criteria; N: index not satisfied with signal criteria.

Yakhak Hoeji 2023;67:15-22 https://doi.org/10.17480/psk.2023.67.1.15
© 2023 Yakhak Hoeji