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Fig. 4.

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Fig. 4. Role of NO in the HU-mediated melanogenesis in B16 melanoma cells. Data (A) represent NO production as a function of time. In the data (B) and (C), quantitative changes in [NO] and melanin contents, respectively, are expressed as a fold increase compared to negative control. In these experiments L-NAME (100 μM) and cPTIO (100 μM) were used as a NOS inhibitor and a NO scavenger, respectively. These drugs were added 30 min before HU (20 μM) application. Data points and columns represent the mean value of four replications with bars indicating SEM. *P<0.05 compared to negative control. #P<0.05 compared to HU alone. Abbreviations: Con, control; cPTIO, 2-(4-carboxy-2-phenyl)-4,4,5,5-tetramethylinidazoline-1-oxyl-3-oxide; HU, hydroxyurea; L-NAME, NG-nitro-L-arginine methyl ester; NO, nitric oxide; NOS, nitric oxide synthase.
Yakhak Hoeji 2022;66:242-8 https://doi.org/10.17480/psk.2022.66.5.242
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