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Fig. 2. 2. Effects of HU on melanin synthesis in B16 melanoma cells. Melanin content was measured after the cells were incubated with each concentration of HU for 48 hr. In the data melanin contents are expressed as a fold increase compared to control condition in which the cells were incubated with HU-free medium. Each column represents the mean value of four replications with bars indicating SEM. *P<0.05 compared to negative control. Abbreviations: HU, hydroxyurea.
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