ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Baseline characteristics of the study subjects
| Control group n=17,781 (%) | BRONJ group n=4,455 (%) | P value | |
|---|---|---|---|
| Sex | 0.810 | ||
| Male | 2283 (12.84) | 578 (12.97) | |
| Female | 15498 (87.16) | 3877 (87.03) | |
| Age group, years | 0.992 | ||
| 60-75 | 3669 (20.63) | 914 (20.52) | |
| 75-79 | 5125 (28.82) | 1286 (28.87) | |
| 80-84 | 4926 (27.70) | 1229 (27.59) | |
| ≥85 | 4061 (22.84) | 1026 (23.03) | |
| Income level | <0.0001 | ||
| Q0-Q2 | 4776 (26.86) | 1381 (31) | |
| Q3-Q4 | 1709 (9.61) | 366 (8.22) | |
| Q5-Q6 | 2062 (11.6) | 470 (10.55) | |
| Q7-Q8 | 3913 (16.38) | 683 (15.33) | |
| Q9-Q10 | 6321 (35.55) | 1555 (34.9) | |
| Route of administration | |||
| Bisphosphonates oral | 16985 (95.52) | 4302 (96.57) | 0.002 |
| Bisphosphonates injections | 935 (5.26) | 334 (7.5) | <0.0001 |
| Comorbidities | |||
| Breast Cancer | 68 (0.38) | 18 (0.4) | 0.835 |
| Prostate Cancer | 123 (0.69) | 41 (0.92) | 0.111 |
| Hypertension | 11470 (64.51) | 3092 (69.41) | <0.0001 |
| Hyperlipidemia | 6584 (37.03) | 1872 (42.02) | <0.0001 |
| Arthrosis | 10188 (57.3) | 3126 (70.17) | <0.0001 |
| Rheumatoid arthritis | 1479 (8.32) | 631 (14.16) | <0.0001 |
| Neuropathies | 3135 (17.63) | 1128 (25.32) | <0.0001 |
| Anemia | 2179 (12.25) | 834 (18.72) | <0.0001 |
| Charlson comorbidity index | <0.0001 | ||
| 0 | 3572 (20.09) | 562 (12.62) | |
| 1-2 | 4223 (23.75) | 888 (19.93) | |
| ≥3 | 9986 (56.16) | 3005 (67.45) | |
| Charlson comorbidites | |||
| Myocardial infarction | 414 (2.33) | 165 (3.7) | <0.0001 |
| Congestive heart failure | 1707 (9.6) | 545 (12.23) | <0.0001 |
| Peripheral vascular disease | 3766 (21.18) | 1187 (26.64) | <0.0001 |
| Cerebrovascular disease | 3749 (21.08) | 1029 (23.10) | 0.003 |
| Renal disease | 312 (1.75) | 148 (3.32) | <0.0001 |
| Cancer | 1301 (7.32) | 466 (10.46) | <0.0001 |
| Rheumatic disease | 290 (1.63) | 149 (3.34) | <0.0001 |
| Peptic ulcer disease | 6522 (36.68) | 1996 (44.8) | <0.0001 |
| Mild liver disease | 3727 (20.96) | 1119 (25.12) | <0.0001 |
| Diabetes without chronic complication | 4503 (25.32) | 1476 (33.13) | <0.0001 |
| Diabetes with chronic complication | 2098 (11.8) | 725 (16.27) | <0.0001 |
| Liver disease | 77 (0.43) | 41 (0.92) | <0.0001 |
| Hemiplegia or paraplegia | 455 (2.56) | 137 (3.08) | 0.056 |
| Metastatic solid tumor | 156 (0.88) | 61 (1.37) | 0.003 |
| AIDS | 3 (0.02) | 1 (0.02) | 0.804 |
| Tooth extraction | 9018 (50.72) | 2775 (62.29) | <0.0001 |
| Co-medication | |||
| Antiplatelet | 6754 (37.98) | 1954 (43.86) | <0.0001 |