ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Summary of pruritogens reported in cholestatic pruritus and their cognate receptors
Pruritogens | Receptors | |
---|---|---|
Bile components | Bile acids | TGR5 (mouse) |
MRGPRX4 (human) | ||
Bilirubin | Mrgpra1 (mouse) | |
MRGPRX4 (human) | ||
Endogenous peptides and other endogenous compounds | Substance P | NK-1R |
MRGPR | ||
Lysophosphatidic acid (LPA) | LPA5 receptor | |
TRPA1/TRPV1/TRPV4 | ||
BAM8-22 | MRGPRX1 (human) | |
Mrgprx1 (mouse) | ||
Serotonin | 5-HT receptors | |
Histamine | H1R/H4R |