ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Summary of pruritogens reported in cholestatic pruritus and their cognate receptors
| Pruritogens | Receptors | |
|---|---|---|
| Bile components | Bile acids | TGR5 (mouse) |
| MRGPRX4 (human) | ||
| Bilirubin | Mrgpra1 (mouse) | |
| MRGPRX4 (human) | ||
| Endogenous peptides and other endogenous compounds | Substance P | NK-1R |
| MRGPR | ||
| Lysophosphatidic acid (LPA) | LPA5 receptor | |
| TRPA1/TRPV1/TRPV4 | ||
| BAM8-22 | MRGPRX1 (human) | |
| Mrgprx1 (mouse) | ||
| Serotonin | 5-HT receptors | |
| Histamine | H1R/H4R | |