약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1.

Summary of pruritogens reported in cholestatic pruritus and their cognate receptors

Pruritogens Receptors
Bile components Bile acids TGR5 (mouse)
MRGPRX4 (human)
Bilirubin Mrgpra1 (mouse)
MRGPRX4 (human)
Endogenous peptides and other endogenous compounds Substance P NK-1R
MRGPR
Lysophosphatidic acid (LPA) LPA5 receptor
TRPA1/TRPV1/TRPV4
BAM8-22 MRGPRX1 (human)
Mrgprx1 (mouse)
Serotonin 5-HT receptors
Histamine H1R/H4R
Yakhak Hoeji 2022;66:115-24 https://doi.org/10.17480/psk.2022.66.3.115
© 2022 Yakhak Hoeji