약학회지

ISSN 0377-9556 (PRINT)
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Table. 4.

Table. 4.

Results of polynomial equations derived for various responses

Variables Observed response
bo X1 X2 X3 X12 X22 X32 X1X2 X1X3 X2X3
Y1 Coefficient 156.21 0.21 21.13 -17.31 -16.87 11.65 -5.15 -11.70 0.71 0.24
P-Value 0.000 0.966 0.001 0.005 0.005 0.034 0.302 0.096 0.914 0.971
Lack of fit 0.000
Equation Y1= −318+71.4 X1+22.2X2+3.9X3−2.700X12+1.864X22−0.824X32−1.87X1X2+0.11X1X3+0.04X2X3 (R2=0.8499 p=0.004)
Y2 Coefficient 56.75 -4.16 -0.39 -0.72 -4.31 -3.92 4.03 -10.92 3.25 -8.74
P-Value 0.000 0.291 0.919 0.852 0.262 0.306 0.293 0.049 0.520 0.103
Lack of fit 0.147
Equation Y2= −27+16.1X1+35.3X2−13.0X3−0.690X12−0.627X22+0.645X32−1.748X1X2+0.520X1X3−1.398X2X3 (R2=0.5846, p=0.248)
Y3 Coefficient 83.92 -2.82 -0.97 -0.51 -4.55 -3.09 2.47 -9.98 0.23 -4.33
P-Value 0.000 0.357 0.747 0.864 0.140 0.301 0.405 0.026 0.954 0.282
Lack of fit 0.064
Equation Y3= −53.7+20.8X1+27.24X2−4.8X3−0.728X12−0.495X22+0.395X32−1.596X1X2+0.036X1X3−0.693X2X3 (R2=0.5825, p=0.252)
Y4 Coefficient 94.58 -0.804 -2.491 0.011 0.49 -1.926 1.238 -4.223 0.925 -0.603
P-Value 0.000 0.317 0.008 0.988 0.524 0.027 0.126 0.002 0.375 0.558
Lack of fit 0.102
Equation Y4=113.5−1.70X1+9.71X2−4.57X3+0.078X12−0.308X22+0.198X32−0.676X1X2+0.148X1X3−0.097X2X3 (R2=0.8079, p=0.012)

X1: Eudragit®L100-55, X2: Pectin, X3: PEO

Y1: Maximun Swelling ratio, Y2: Dissolution rate at 6 h, Y3: Dissolution rate at 12 h, Y4: Dissolution rate at 24 h

Yakhak Hoeji 2022;66:76-89 https://doi.org/10.17480/psk.2022.66.2.76
© 2022 Yakhak Hoeji