약학회지

ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1.

Physical properties of hot melt extruded filaments containing sarpogrelate HCl (Mean±SD, n=3)

Run # Dependent variables (%) Flexibility Elasticity Thickness (mm) Drug content (%)
X1 X2 X3
F1 10.00 0.00 5.00 2.33±0.58 3.67±0.58 1.50±0.01 108.54±0.59
F2 15.00 0.00 5.00 1.67±0.58 4.00±0.00 1.50±0.02 100.61±0.83
F3 10.00 5.00 5.00 3.00±0.00 2.33±0.58 1.50±0.01 106.91±0.27
F4 15.00 5.00 5.00 3.67±0.58 1.67±0.58 1.50±0.01 100.37±0.68
F5 10.00 0.00 10.00 4.00±0.00 2.67±0.58 1.50±0.01 100.04±0.35
F6 15.00 0.00 10.00 3.33±0.58 3.00±1.00 1.50±0.01 98.90±0.25
F7 10.00 5.00 10.00 4.67±0.58 1.00±0.00 1.49±0.01 97.25±0.23
F8 15.00 5.00 10.00 5.00±0.00 1.00±0.00 1.50±0.01 100.03±0.32
F9 8.30 2.50 7.50 3.67±0.58 3.00±0.00 1.49±0.02 98.03±0.68
F10 16.70 2.50 7.50 5.00±0.00 1.00±0.00 1.50±0.01 99.80±0.46
F11 14.20 0.00 9.20 2.00±0.00 2.67±0.58 1.49±0.01 100.13±0.67
F12 12.50 6.70 7.50 5.00±0.00 1.33±0.58 1.50±0.01 100.69±0.03
F13 12.50 2.50 3.30 1.67±0.58 3.33±0.58 1.50±0.01 99.89±0.15
F14 12.50 2.50 11.70 5.00±0.00 1.00±0.00 1.49±0.02 99.41±0.57
F15* 12.50 2.50 7.50 4.83±0.38 1.94±0.42 1.49±0.01 100.58±1.45

X1: Eudragit® L 100-55, X2: Pectin, X3: PEO

*mean value expressed by 6 times of measurement

All formulation contained 60% of sarpogrelate HCl

Yakhak Hoeji 2022;66:76-89 https://doi.org/10.17480/psk.2022.66.2.76
© 2022 Yakhak Hoeji