약학회지
YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1.

Glutaminase Isoforms

Gene Isoform Function in cancer cells Correlation between expression and cancer Catalytic activity Location Small molecule inhibitors
Gls1 KGA Growth, proliferation and survival Close Yes Cytosol DON, 1, 5-N, N′-disubstituted-2-(substituted benzenesulphonyl) glutamamide analogues, physapubescin, 968, thiazolidine-2,4-dione derivative, BPTES, CB-839
GAC Yes Mitochondria only
GAM Unknown - - - -

Gls2 LGA Tumor repression or activation Arguable Yes Mitochondria DON, 1, 5-N, N′-disubstituted-2-(substituted benzenesulphonyl) glutamamide analogues, ardisianone (AV-1)
GAB Yes -
Yakhak Hoeji 2021;65:344-8 https://doi.org/10.17480/psk.2021.65.5.344
© 2021 Yakhak Hoeji