약학회지
YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Fig. 3.

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Fig. 3. Effect of AA-5-HT to Cannabinoid receptor and TRPV1. TRPV1 and CB1 is located in the plasma membrane. TRPV1 behaves like a pro-nociceptive ion channel, whereas CB1 funcions as if an anti-nociceptive receptor. Anandamide is an endocannabinoid which is hydrolyzed by FAAH. Since AA-5-HT can inhibit both FAAH and TRPV1, AA-5-HT in return activates CB1 by inhibiting anandamide, and also inhibits TRPV1 simultaneously.
Yakhak Hoeji 2021;65:237-45 https://doi.org/10.17480/psk.2021.65.4.237
© 2021 Yakhak Hoeji