약학회지
YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 2.

Table. 2.

17 Herbal medicine with drug interaction7,10,12)

No Botanical name Drug
1 Astragalus membranaceus (황기) Cyclophosphamide Decrease the efficacy of cyclophosphamide
2 Bupleurum chinense (시호) Antidepressant Increase the risk of Serotonin syndrome
3 Cimicifuga dahurica (승마) CYP2D6 substrates CYP2D6 inhibitor
4 Citrus aurantium (지각) CYP2D6 substrates, CYP3A4 substrates (especially Dextromethorphan) CYP2D6 inhibitor, CYP3A4 inhibitor(increase Cmax and side effect of dextromethorphan)
5 Coptis chinensis (황련) Cyclosporine, CYP3A4 substrates Decrease the metabolism of cyclosporine, CYP3A4 inhibitor
6 Dolichos lablab (백편두) Theophylline Increase the theophylline toxicity
7 Ephedra sinica (마황) Anticonvulsants, Dexamethasone Decrease the efficacy of anticonvulsants, Increase the clearance of dexamethasone
8 Glycyrrhiza uralensis (감초) Oral Corticosteroid, CYP2B6 substrates, CYP2C9 substrates, CYP3A4 substrates, Cardiotonic agent, Diuretics Increase the efficacy and serum concentration of oral corticosteroids, CYP 2B6 inhibitor, CYP 2C9 inhibitor of inducer, CYP 3A4 inhibitor of inducer, Increase the digoxin toxicity due to potassium loss
9 Lycium chinense (구기자) Antidiabetic Decrease blood glucose
10 Magnolia officinalis (후박) Oral corticosteroids, Muscle relaxants Increase the serum concentration of Oral corticosteroids, Increase the side effect of muscle relaxants(dizziness, fatigue)
11 Panax ginseng (인삼) Warfarin, Immunosuppressants, CYP 2D6 substrates, CYP 3A4 Substrates Decrease the efficacy of warfarin, Decrease the efficacy of immunosuppressants, CYP2D6 inhibitor, CYP3A4 inhibitor
12 Phellodendron amurense (황백) Cyclosporine, CYP3A4 substrates Decrease the metabolism of cyclosporine, CYP3A4 inhibitor
13 Pueraria lobata (갈근) Methotrexate Decrease the clearance of MTX
14 Rheum palmatum (대황) Corticosteroid, Digoxin, diclofenac Increase the loss of potassium, Increase the risk of renal failure (diclofenac side effect)
15 Schizandra chinensis (오미자) CYP2C9 substrates, CYP3A4 substrates, tacrolimus CYP2C9 inducer, CYP3A4 inhibitor or inducer, Increase AUC and Cmax of tacrolimus
16 Scutellaria baicalensis (황금) Benzodiazepines, CNS depressants, CYP1A2 substrates, CYP2C19 substrates, Increase of the efficacy and the risk of side effect of benzodiazepines, Increase the risk of CNS side effect (sedation), CYP1A2 inhibitor, CYP2C19 Inhibitor
17 Tribulus terrestris (백질려) CYP 3A4 Substrates CYP3A4 inhibitor
Yakhak Hoeji 2021;65:72-86 https://doi.org/10.17480/psk.2021.65.2.72
© 2021 Yakhak Hoeji