약학회지
YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 1.

Table. 1.

Cytochrome P450s (CYP450) and their substrate drugs

CYP450 Substrate drugs
CYP1A2 acetaminophen, penacetin, lidocaine, olanzapine, clozapine, duloxetine, nabumetone, propranolol, guanabenz, triamterene, tacrine, tizanidine, zolpidem
CYP2B6 efavirenz, bupropion, artemisinin, propofol, ketamine
CYP2C8 rosiglitazone, pioglitazone, amiodarone, paclitaxel, amodiaquine
CYP2C9 warfarin, phenytoin, valproic acid, candesartan, losartan, glibenclamide, tolbutamide CYP2C19 clopidogrel, progesterone, melatonin
CYP2C19 clopidogrel, progesterone, melatonin
CYP2D6 propafenone, mexiletine, flecainide, amitriptyline, paroxetine, venlafaxin, aripiprazole, risperidone, bufuralol, metroprolol, tamoxifen, codeine, tramadol
CYP2E1 ethanol, acetone, organic solvent, chlorzoxazone, paracetamol, lauric acid
CYP3A4 cyclosporin A, tacrolimus, erythromycin, taxol, ifosfamide, tamoxifen, benzodiazepines, statins, testosterone, progesterone, androstenedione, cortisol, bile acids
Yakhak Hoeji 2020;64:8-20 https://doi.org/10.17480/psk.2020.64.1.8
© 2020 Yakhak Hoeji