ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Cytochrome P450s (CYP450) and their substrate drugs
| CYP450 | Substrate drugs |
|---|---|
| CYP1A2 | acetaminophen, penacetin, lidocaine, olanzapine, clozapine, duloxetine, nabumetone, propranolol, guanabenz, triamterene, tacrine, tizanidine, zolpidem |
| CYP2B6 | efavirenz, bupropion, artemisinin, propofol, ketamine |
| CYP2C8 | rosiglitazone, pioglitazone, amiodarone, paclitaxel, amodiaquine |
| CYP2C9 | warfarin, phenytoin, valproic acid, candesartan, losartan, glibenclamide, tolbutamide CYP2C19 clopidogrel, progesterone, melatonin |
| CYP2C19 | clopidogrel, progesterone, melatonin |
| CYP2D6 | propafenone, mexiletine, flecainide, amitriptyline, paroxetine, venlafaxin, aripiprazole, risperidone, bufuralol, metroprolol, tamoxifen, codeine, tramadol |
| CYP2E1 | ethanol, acetone, organic solvent, chlorzoxazone, paracetamol, lauric acid |
| CYP3A4 | cyclosporin A, tacrolimus, erythromycin, taxol, ifosfamide, tamoxifen, benzodiazepines, statins, testosterone, progesterone, androstenedione, cortisol, bile acids |