ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)
ISSN 2383-9457 (ONLINE)
Clinical impacts on drug-drug interactions
| Perpetrator drugs | Victim drugs | Clinical drug-drug interactive outcomes |
|---|---|---|
| Norvir | Voriconazole | Increased blood concentration |
| Diltiazem | Warfarin | Lack of anticoagulation effect. |
| Pravastatin, tolbutamide, hydrochlorothiazide | No significantly different pharmacokinetic profile | |
| Midefradil | beta-blockers | Heart shock |
| Simvastatin | Myopathy appears in hypertensive patients | |
| Fluoxetine | Thioridazine | Severe ventricular arrhythmia due to elevated blood levels |
| Phenytoin, carbamazepine | Increased blood concentration and toxicity | |
| Haloperidol, clozapine | Increased blood concentration | |
| Pimozide | Prolongation of QT intervals | |
| Alprazolam | Increased blood concentration and psychomotor function is reduced | |
| Warfarin | Side effects of anticoagulants, including increased bleeding | |
| Ketoconazole, erythromycin | Terfenadine | Severe heart toxicity |
| Clarithromycin | Theophylline | Increased Cmax and AUC (approx. 20%) |
| Carbamazepine | Increased blood concentration | |
| Ritonavir | Need to reduce the dose of clarithromycin in patients with renal impairment | |
| Oral anticoagulants | Increased effect of anticoagulants | |
| Digoxin | Digitalis toxicity | |
| Cyclosporine | Diclofenac, methotrexate | Increased AUC |
| Colchicine, statins, prednisolone | Decreased CL | |
| Digoxin | Digitalis toxicity | |
| Colchicine | Myopathy and neuropathy in patients with renal failure | |
| Sirolimus | Increased blood concentration in patients with renal failure | |
| Silybin | Indinavir | Decreased AUC and blood concentration level (9~25%) |