약학회지
YAKHAK HOEJI
ISSN 0377-9556 (PRINT)
ISSN 2383-9457 (ONLINE)

Table. 3.

Table. 3.

Specific strong index inhibitors, inducers, and sensitive index substrates of cytochrome P450 (CYP)

CYP450 Strong index inhibitors Strong index inducers Sensitive index substrates
CYP1A2 fluvoxamine montelukast (moderate) caffeine, tizanidine
CYP2B6 ticlopidine (weak) rifampin (moderate) bupropion, efavirenz
CYP2C8 clopidogrel, gemfibrozil rifampin (moderate) repaglinide
CYP2C9 fluconazole (moderate) rifampin (moderate) warfarin, tolbutamide
CYP2C19 fluvoxamine rifampin S-phenytoin, omeprazole
CYP2D6 fluoxetine, paroxetine atomoxetine,desipramine, dextromethorphan
CYP3A4 clarithromycin, itraconazole phenytoin, rifampin midazolam, triazolam
Yakhak Hoeji 2020;64:8-20 https://doi.org/10.17480/psk.2020.64.1.8
© 2020 Yakhak Hoeji